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3rd Biennial Meeting

Sex Differences in the Immune System 

2024 Meeting Programme

(Download PDF)

Wednesday, June 12th, 2024

 

Registration

4:00pm – 6:00pm

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Welcome and Opening Remarks: David Page & Lydia Lynch

6:00pm

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Public Outreach Event with Prof. Rose Anne Kenny

6:15pm, Trinity Business School

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Thursday, June 13th, 2024

Session 1: Genetics/Sex-linked chromosomes & hormones

Chair 1: Cliona O’Farrelly, TCD
Chair 2: Andrea Lisco, NIH

9:15am – 11:15am

  • David Page, Whitehead Institute, "Stable and robust Xi and Y transcriptomes drive cell-type-specific autosomal (and Xa) responses in vivo and in vitro, in four human cell types"

  • Margaret McCarthy, University of Maryland School of Medicine, "Sex differences in the brain at the intersection of neuroscience, endocrinology and immunology"

  • Diana Dou, Stanford University, "Lnc”ing Xist ribonucleoproteins to the female sex bias in autoimmunity"

  • Jean-Charles Guery, Inserm, "X chromosome inactivation escape: a driving force in B cell systemic autoimmunity"

 

Break

11:15 am – 11:45am

 

Session 2: Immunometabolism

Chair 1: Lizzy Rosser, UCL

Chair 2: Emily Day, TCD

11:45am – 1:15pm

  • Lydia Lynch, Princeton University & Trinity College Dublin, "Linking sex differences in systemic metabolism and immunometabolism"

  • Vishnu Shankar, Stanford University,"Oxidative Stress is a shared characteristic of ME/CFS and Long COVID"

  • Jaclyn Kline, Harvard Medical School,"Sex differences in T cell metabolism"

  • Luke O’Neill, Trinity College Dublin, "A break in mitochondrial endosymbiosis as a basis for inflammatory diseases"

 

Lunch

1:15pm – 2:00pm

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Session 3: Sex differences across the lifespan

Chair 1: Michal Tal, MIT
Chair 2: Sarah Doyle, TCD

2:00pm – 3:30pm

  • Darragh Duffy, Institut Pasteur, "Understanding sex and age effects on healthy immune responses"

  • Dong Gao, Shanghai Institute of Biochemistry and Cell Biology,  Chinese Academy of Sciences,"Sex differences orchestrated by androgens at single-cell resolution"

  • Rebecca Harris, Whitehead Institute, "Sex chromosomes regulate gene expression more robustly and stably than sex hormones in immune cells from cis- and transgender individuals"

  • Maureen Su, University of California, Los Angeles, "The X chromosome and Immunity"

 

Break

3:30pm – 4:00pm

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Session 4: Disease/Cancer

Chair 1: Seth Scanlon, Science Immunology

Chair 2: Rebecca Coll, QUB

4:00pm – 5:15pm

  • Amy Moran, Oregon Health & Science University, "Mechanisms of androgen receptor regulation of immunity"

  • Sebastian Schloer, Leibniz Institute of Virology, "The RNA helicase DDX3 mediates sex dimorphism in the IFNα response of plasmacytoid dendritic cells upon viral sensing"

  • Molly Ingersoll, Institut Cochin, "The impact of sex on bladder mucosal immunity"

Poster Session & Presentation of EFIS Travel Fellowships

5:15pm – 7:15pm, Concourse

             

Networking Fork Supper

7:30pm, Medley, Fleet St.

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Friday, June 14th, 2024

 

Session 5: Viral diseases, complement & vaccines 

Chair 1: Sabra Klein, John Hopkins

Chair 2: Kiva Brennan, TCD

9:30am – 11:15am

  • Mihai Netea, Radboud University Medical Center, "Variation in trained immunity responses"

  • Claudia Kemper, National Heart, Lung & Blood Institute, NIH, "Cell-autonomous complement as determinant of sex-specific immunity?"

  • Lorena Garcia-del Rio, Trinity College Dublin, "IL33 modulates vaccine adjuvant induced cell-mediated immunity in a sex-dependent manner" 

  • Ed Lavelle, Trinity College Dublin, "Sex differences in immune responses to vaccine adjuvants"

 

Break

11:15am – 11:45am

 

Session 6: Systems Biology/Translational Immunology 

Chair 1: Nollaig Bourke, TCD

Chair 2: Jamie Sugrue, Institut Pasteur

11:45am – 1:15pm

  • Marc Dionne, Imperial College London, "Sex differences in Drosophila humoral immunity: causes and consequences"

  • Kyuson Yun, Houston Methodist Research Institute, "Sex biased YAP1 function at the cancer:immune interface"

  • Elizabeth Maloney, Institut Pasteur, "Sex-specific effects of temperature on the immune system"

  • Petter Brodin, Karolinska Institute & Imperial College London, "Immune system adaptation during gender-affirming sex-hormone treatment"

 

Lunch

1:15pm – 2:00pm

 

Session 7: Inflammation & Infection

Chair 1: Dorothee Schwinge, UKE

Chair 2: Irini Sereti, NIH

2:00pm – 4:00pm

  • Jenny Regan, The University of Edinburg, "Sex-specific regulation of phagocytes determines susceptibility to Staphylococcus aureus
    infection"

  • Shannon Dunn, University of Toronto, "Obesity Intensifies Sex-specific Interferon (IFN) Signaling to Selectively Worsen Central Nervous System Autoimmunity in Females"

  • Rachael Bell, Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, "Regulatory T cells mediate the increased susceptibility of females to Pseudomonas aeruginosa infection"

  • Marcus Altfeld, Leibniz Institute of Virology, "Sex differences in Type I IFN responses"

  • Yasmine Belkaid, National Institute of Allergy & Infectious Diseases, NIH & Institut Pasteur, "Tissue specific sex immune control"

 

Break

4:00pm – 4:30pm

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Plenary Speaker: Nick Lane, University College London

"Why do mitochondria produce sex differences?"

4:30 – 5:30

 

Closing Remarks

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