Wednesday, June 12th, 2024

 

Registration

4:00pm – 6:00pm

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Welcome and Opening Remarks: David Page & Lydia Lynch

6:00pm

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Public Outreach Event with Prof. Rose Anne Kenny

6:15pm, Trinity Business School

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Thursday, June 13th, 2024

Session 1: Genetics/Sex-linked chromosomes & hormones

Chair 1: Cliona O’Farrelly, TCD
Chair 2: Andrea Lisco, NIH

9:15am – 11:15am

• David Page, Whitehead Institute, "Stable and robust Xi and Y transcriptomes drive cell-type-specific autosomal (and Xa) responses in vivo and in vitro, in four human cell types"

• Margaret McCarthy, University of Maryland School of Medicine, "Sex differences in the brain at the intersection of neuroscience, endocrinology and immunology"

• Diana Dou, Stanford University, "Lnc”ing Xist ribonucleoproteins to the female sex bias in autoimmunity"

• Jean-Charles Guery, Inserm, "X chromosome inactivation escape: a driving force in B cell systemic autoimmunity"

 

Break

11:15 am – 11:45am

 

Session 2: Immunometabolism

Chair 1: Lizzy Rosser, UCL

Chair 2: Emily Day, TCD

11:45am – 1:15pm

• Lydia Lynch, Princeton University & Trinity College Dublin, "Linking sex differences in systemic metabolism and immunometabolism"

• Vishnu Shankar, Stanford University,"Oxidative Stress is a shared characteristic of ME/CFS and Long COVID"

• Jaclyn Kline, Harvard Medical School,"Sex differences in T cell metabolism"

• Luke O’Neill, Trinity College Dublin, "A break in mitochondrial endosymbiosis as a basis for inflammatory diseases"

 

Lunch

1:15pm – 2:00pm

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Session 3: Sex differences across the lifespan

Chair 1: Michal Tal, MIT
Chair 2: Sarah Doyle, TCD

2:00pm – 3:30pm

• Darragh Duffy, Institut Pasteur, "Understanding sex and age effects on healthy immune responses"

• Dong Gao, Shanghai Institute of Biochemistry and Cell Biology,  Chinese Academy of Sciences,"Sex differences orchestrated by androgens at single-cell resolution"

• Rebecca Harris, Whitehead Institute, "Sex chromosomes regulate gene expression more robustly and stably than sex hormones in immune cells from cis- and transgender individuals"

• Maureen Su, University of California, Los Angeles, "The X chromosome and Immunity"

 

Break

3:30pm – 4:00pm

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Session 4: Disease/Cancer

Chair 1: Seth Scanlon, Science Immunology

Chair 2: Rebecca Coll, QUB

4:00pm – 5:15pm

• Amy Moran, Oregon Health & Science University, "Mechanisms of androgen receptor regulation of immunity"

• Sebastian Schloer, Leibniz Institute of Virology, "The RNA helicase DDX3 mediates sex dimorphism in the IFNα response of plasmacytoid dendritic cells upon viral sensing"

• Molly Ingersoll, Institut Cochin, "The impact of sex on bladder mucosal immunity"